A “best” vape assortment in 2025 means more than a long menu. For multi-state operators (MSOs), the leaders pair breadth of formats (distillate, live resin, live rosin, liquid diamonds), multiple device ecosystems (510 carts, pods, disposables, all-in-ones), clear labeling and testing transparency, and availability across several states at price points. Judged by those criteria, here’s where the selection stands out right now.
Green Thumb Industries (RISE) — anchored by RYTHM
GTI’s RYTHM line is one of the most complete vape families in U.S. cannabis, spanning standard cartridges, PAX pods, and “Live Vape” SKUs built from fresh-frozen material. Beyond the variety, the brand has sustained multi-state velocity, with industry trackers ranking RYTHM among the country’s top-selling brands and attributing a meaningful share of its revenue to vapes. That mix of formats plus scale makes GTI a consistent first stop for shoppers who prioritize flavor-forward oil without additives.
Curaleaf — powered by Select
Curaleaf earns a spot on selection alone. Select runs three distinct device ecosystems: Briq (high-capacity rechargeable AIO), Cliq (gravity-fed pod), and Stiq/standard 510 options. Because Curaleaf operates coast-to-coast, those form factors surface on menus from Florida to Illinois, often at multiple potency and price tiers. For buyers, that means a high likelihood of finding the same device family across states, plus the ability to choose between value, mid, and premium offerings in distillate or terpene-forward oils.
Cresco Labs — Liquid Live Resin at scale
If your definition of “best” leans toward strain-faithful live extracts, Cresco’s Liquid Live Resin line is unusually consistent across markets. These single-strain cartridges aim to preserve fresh terpene profiles, and because Cresco controls Sunnyside retail in several states, you’ll typically see multiple LLR options in stock alongside value 510 carts. That combination—live resin variety plus reliable availability—earns Cresco a place among the most shopper-friendly vape portfolios.
Verano — premium meets value with Verano + Savvy
Verano’s namesake vapes cover the premium end, while Savvy extends into wallet-smart formats, including pens and one-gram cartridges. The company’s recent expansion of these brands specifically targets fast-growing categories, signaling continued investment in vape assortment depth. In practical terms, customers can pick between refined, strain-specific oil and larger-format/value SKUs under the same MSO umbrella—a useful range for mixed-budget households.
Trulieve — Florida’s broadest proprietary pod ecosystem
Trulieve’s proprietary TruPOD/TruSTIK system remains one of the most comprehensive closed-pod ecosystems in the U.S., with dozens of SKUs cycling through Florida menus at any given time. Recent battery upgrades add variable-voltage control and quality-of-life features, and the catalog spans disty, CDT-enhanced, and live options depending on store. For medical patients who prefer pods over 510 carts, Trulieve’s depth is hard to beat within a single state.
Honorable mentions
• Ascend Wellness (Ozone) regularly promotes broad, value-driven Ozone cart lineups—good for price-sensitive shoppers.
• Jushi (The Lab) covers cured, liquid-diamonds, and solventless offerings in select markets.
• TerrAscend (Kind Tree) and AYR (Kynd) provide balanced menus of cartridges and disposables with cannabis-derived terpenes and full-spectrum options.
• The Cannabist Company (Seed & Strain) continues to expand brand availability state-by-state.
Bottom line
If you’re chasing the widest device ecosystem and coast-to-coast presence, Curaleaf/Select leads. For live-terp authenticity, Cresco’s LLR is a reliable bet. For a balanced premium-to-value ladder under one roof, Verano stands out. And for a closed-pod experience with massive in-state variety, Trulieve is the clear Florida leader. Data-watchers should keep an eye on GTI’s RYTHM as a bellwether: strong vape share plus multi-format breadth often maps to better selection market-by-market.